Plain language a quick outline and core facts
This marketed tablet combines two active substances: tadalafil plus dapoxetine. The product is intended for adult men who require treatment for erectile dysfunction together with on-demand management of premature ejaculation.
Typical single-tablet composition often seen in international supplies is tadalafil 20 mg combined with dapoxetine 60 mg. The idea behind the combination is to provide a long-acting phosphodiesterase type 5 inhibitor to support erection and a short-acting selective serotonin reuptake agent to delay ejaculation when taken before sexual activity.
For quick navigation use the menu above or jump directly to details on dosing, frequent the act of interactions boost coordination., or Australian law information: guidance on dose and timing, effective interactive engagements require clear communication., annotations on the law in Australia.
The way it works
Tadalafil - supporting erections
Tadalafil reduces the activity of the PDE5 enzyme, phosphodiesterase type 5. By doing so it enhances the vasodilatory response in the genital tissues during sexual stimulation, helping to achieve and maintain an erection. The duration of effect for tadalafil in many men can extend to about 36 hours after a single dose.
Dapoxetine - delaying ejaculation
Dapoxetine is a short-acting SSRI used on demand for premature ejaculation in men aged 18 to 64 where it is licensed. It modifies serotonin signalling involved in ejaculatory control and typically reaches its maximal effect some 40 to 50 minutes after dosing.
Use and administration guidance
Follow the directions of your prescriber or pharmacist. The points below are general recommendations only and do not replace personalised medical advice.
- Swallow the tablet whole with plain water. Do not crush or chew the tablet.
- Take the combination tablet about 30 to 60 minutes before anticipated sexual activity to align both components with expected onset times.
- It can be taken with or without food; heavy, high-fat meals may delay onset.
- Avoid excessive alcohol and avoid grapefruit products where possible because they can increase undesired consequences or alter blood levels.
- Remember that tadalafil and dapoxetine have different pharmacokinetic profiles; plan timing according to the activity you expect.
If you have doubts about timing or whether this combined product is right for you, speak in cooperation with your prescriber. See more dose cadence and timing for further detail.
Dose schedule and timing
Use the smallest effective dose for the shortest period necessary, under clinical supervision.
- Commonly seen fixed-dose tablet: tadalafil 20 mg plus dapoxetine 60 mg taken as needed before sexual activity.
- Do not exceed one tablet in any 24 hour period. Tadalafil remains active for an extended time so frequency should be discussed with your healthcare provider.
- If a planned dose is missed, take it only if sexual activity is still intended that same day; do not double up doses.
- In some cases a prescriber may prefer separate prescriptions for tadalafil and for a PE agent to allow dose flexibility. Ask your clinician about tailored options.
For patients on interacting medicines or with organ impairment a clinician may adjust the regimen. Seek clarification from a professional your prescriber for personalised dose amount expert counsel.
Data a storage solution should balance access and protection. and safeguarding
- Store at room temperature, with the ideal 20 to 25 degrees Celsius (68 to 77 degrees Fahrenheit).
- Keep the product dry and avoid direct heat and bright light.
- Put medicines in a location that children and pets cannot access or notice.
Drug communication in action alerts
Both tadalafil and dapoxetine interact with a range of other substances. Disclose all prescription drugs, over-the-counter medicines, supplements, and recreational substances to your prescriber.
- Nitrates or nitric oxide donors (for example glyceryl trinitrate, isosorbide dinitrate, nitroprusside, or "poppers"): combining with tadalafil can cause a marked drop in blood pressure and is strictly contraindicated.
- Alpha-blockers and many antihypertensive agents: when combined with tadalafil they may cause symptomatic low blood pressure; timing and dose adjustments may be needed.
- Strong CYP3A4 inhibitors (for example ketoconazole, itraconazole, ritonavir, cobicistat, clarithromycin): these can raise tadalafil and possibly dapoxetine blood levels and may require avoidance or dose changes.
- CYP3A4 inducers (for example rifampicin, carbamazepine, phenytoin, St Johns wort blossom): could reduce effectiveness by increasing clearance.
- Other serotonergic medicines (SSRIs, SNRIs, MAO inhibitors, linezolid, lithium, certain triptans): combined use with dapoxetine increases the risk of serotonin syndrome.
- Ethyl alcohol drink: can increase the chance of dizziness, fainting, chronic head pain and impaired judgement. Avoid heavy drinking when using this medicine.
- Do not merge with other ED drugs without explicit medical advice.
Ask your pharmacist to check for social interactions at scale reveal systemic patterns. if you start, stop or change any other medicine. See safe handling with protective guidelines and risk alerts for more safety measures to implement.
Cautions, warning signals, and safety guidelines
Do not take this combination if any of the following apply to you:
- Known hypersensitivity to tadalafil, dapoxetine or any excipient in the tablet.
- Severe disruption of liver function or severe renal disease requiring dialysis.
- Concurrent use of nitrates or recreational nitrite inhalants.
- Recent major cardiac events such as myocardial infarction in the last 90 days, stroke in the last 6 months, unstable angina, severe heart failure, or uncontrolled blood pressure.
Inform your prescriber if you have a history or current problems such as:
- Blood disorders, peptic ulcer disease, bleeding tendencies, or conditions predisposing to priapism.
- Penile anatomical deformities, major cardiac conditions, significant arrhythmias or aortic stenosis.
- Neurological or psychiatric illness including history of seizures, mania, or hyponatraemia.
- Allergies to medicines, food additives or if using herbal remedies or complementary medicines.
Practical guidance to improve safety:
- The product may cause dizziness, drowsiness or visual changes; avoid driving or operating machinery if affected.
- If chest pain, sudden severe headache, sudden loss of vision or hearing, fainting, severe dizziness or other serious symptoms occur during sexual activity, stop and seek emergency care immediately.
- This tablet does not protect against sexually transmitted infections. Use barrier methods where appropriate.
- Not licensed for women or children under 18 years.
- If an erection persists beyond 4 hours seek urgent medical treatment to avoid permanent damage.
Possible adverse effects and safety
Most adverse reactions are mild to moderate and resolve without treatment. Contact a healthcare professional if effects are severe or persistent.
Most commonly reported lingering reactions reported include:
- Head pressure with facial reddening and nasal congestion or runny nose.
- Feeling dizzy, sleepiness or lightheadedness.
- Nausea, parched mouth, upset stomach or diarrhea.
- Pain along the back, muscle aches, insomnia or restlessness.
Less frequent but serious events - seek immediate care if they occur:
- Painful erection lasting more than 4 hours (priapism).
- Severe allergic reactions including swelling of the face, tongue or throat and difficulty breathing.
- Sudden loss of vision or sudden hearing loss, sometimes with tinnitus and dizziness.
- Symptoms of serotonin syndrome with dapoxetine such as agitation, high temperature, sweating, tremor, muscle rigidity, confusion or rapid heartbeat.
Other treatment modalities and analogous therapies
If a fixed-dose combination is unsuitable, prescribers may suggest single agents or non-drug strategies. Choice depends on medical history, pharmacokinetic and pharmacodynamic contact and responses among teammates fuel progress. between drugs, patient preference and local availability.
Erectile dysfunction management options
- Tadalafil alone - available in on-demand 10 to 20 mg doses or as low-dose daily regimens such as 2.5 to 5 mg.
- Sildenafil (generic or Viagra) - shorter acting, often used first-line.
- Vardenafil (Levitra) - an an additional choice to sildenafil for some patients.
- Spedra (Avanafil) - may work faster in some men; local pharmacy stock varies.
- Non-oral options - vacuum erection devices or intracavernosal injections such as alprostadil for those unable to use or who do not respond to oral agents.
Possible remedies for premature ejaculation
- Dapoxetine taken on demand where it is licensed and available.
- Topical anesthetic preparations (lidocaine/prilocaine creams or sprays) to reduce penile sensitivity.
- Behavioural approaches such as the stop-start or squeeze methods and pelvic floor exercises.
- Off-label oral SSRIs for daily use, for example sertraline or paroxetine, when advised by a prescriber.
Discuss these options with an Australian registered prescriber. For cost and pricing model and availability see estimated price levels and for legal issues see Australian legal study notes.
Estimated subscription pricing in AUD
Cost levels in Australia depend on brand, pack size, pharmacy, and whether a product is subsidised. The figures below are approximate and should be checked with local pharmacies before purchase.
- Generic tadalafil 10-20 mg: roughly AUD 1.50 to AUD 7.00 per tablet when bought in larger packs; branded Cialis can be about AUD 20 to AUD 30 per tablet depending on pack size.
- Sildenafil 50-100 mg: generics commonly cost around AUD 0.80 to AUD 5.00 per tablet; branded Viagra often retails near AUD 15 to AUD 30 per tablet.
- Avanafil, also known as Spedra 50-200 mg: where available typical cost structure are around AUD 8 to AUD 20 per tablet.
- Topical lidocaine/prilocaine products for PE: about AUD 20 to AUD 45 per pack depending on size and brand.
- Dapoxetine 30-60 mg: not widely supplied in Australian pharmacies; overseas vendors may list prices around AUD 3 to AUD 10 per tablet but importing carries risks.
- Fixed-dose tadalafil 20 mg plus dapoxetine 60 mg tablets advertised by international sellers often show prices in the range AUD 6 to AUD 15 per tablet; availability and legality in Australia vary - see legal commentary.
Always consult your pharmacist for the most current local prices and to confirm whether a prescription is required.
Jurisprudence notes from Australia
- Tadalafil is a Prescription Only medicine (Schedule 4) in Australia and lawfully requires a prescription from an Australian-registered prescriber for supply from chemist shops.
- Some medicines such as dapoxetine or fixed-dose combinations might not be listed on the Australian Register of Therapeutic Goods (ARTG) and so are not routinely available in Australian drugstore chains.
- Personal importation rules: under the Therapeutic Goods Administration (TGA) Import Scheme for Personal Use some individuals may import up to a three-month supply in specific circumstances, usually with an appropriate prescription. Non-ARTG items are at risk of being detained by customs.
- Online sales and advertising of prescription medicines to the public are restricted under Australian law. Overseas websites may sell counterfeit or substandard medicines; exercise caution.
- Driving and workplace safety: if you experience dizziness or drowsiness after taking the medicine avoid driving or performing tasks that require full alertness in line with Australian road safety laws.
For current rules consult the TGA website, state health authorities, your pharmacist or prescriber before importing or using prescription medicines obtained outside Australia.
More details
- Conditions covered: erectile dysfunction and premature ejaculation in adult men.
- Timing: tadalafil can begin to work within about 20 to 60 minutes in some men and may provide support for up to 36 hours; dapoxetine typically peaks around 40 to 50 minutes after a dose.
- Do not unite with other ED medications unless a clinician advises it.
- If you have a serious adverse event seek emergency medical help immediately.
Healthcare professionals can help determine whether a combined tablet, separate agents, or non-drug approaches are most appropriate based on health status and current medicines.
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