The a concise overview of the apexic and basics
Quetiapine, often known by the brand name Seroquel, is an atypical antipsychotic used primarily for schizophrenia and bipolar disorder. It is also prescribed in some cases to augment antidepressants when depression is resistant to standard therapy.
In Australia quetiapine is supplied as oral tablets in several potencies and as different formulations, including immediate-release and extended-release forms. Common tablet strengths include 25 mg, 50 mg, 100 mg, 200 mg and 300 mg, though availability differs by brand and pack size.
Quick safety checklist before starting
Before you launch quetiapine, make sure you discuss the following with your prescriber or pharmacist so that any necessary preventive precautions or the act of monitoring can be arranged:
- Any known heart problems, history of fainting, irregular heartbeat or prior heart attack
- Current or past seizures, epilepsy, or significant head injury
- The ailment named diabetes, obesity or a strong family history of elevated blood glucose
- Disease of the liver or kidneys which can influence dosing
- Movement disorders (for example Parkinson disease) or past extrapyramidal symptoms
- Plans for becoming pregnant, current pregnancy or breastfeeding
- Use of alcohol, recreational drugs, herbal supplements or other medicines (prescription and over the counter)
- Allergies to quetiapine or any tablet excipients
- Eye disease such as glaucoma and any recent vision changes
- Personal or family history of suicidal behaviour or sudden mood shifts
Older adults (65 and over) are typically more vulnerable to sedation and blood pressure changes; they may require lower starting doses. Use in children and adolescents is restricted to specific portents and normally supervised by a specialist.
Administration techniques and dosing
- Follow the dosing schedule exactly as written on your prescription. Maintain consistent timing for each dose to help stability.
- Consume the pills with a glass of water. If you feel nauseous, taking the dose with food may reduce stomach upset.
- Do not crush or chew extended-release tablets unless a pharmacist confirms it is safe. Immediate-release and extended-release tablets are not interchangeable without advice.
- Any change in dose, or stopping the drug, should be done under medical supervision and usually tapered to avoid withdrawal symptoms and relapse.
- For urgent a drug overdose case assistance in Australia call Triple Zero (000) or contact the Poisons Information Centre on 13 11 26.
If you want to review the guidance on missed a doses, see Steps to take for a dose was omitted.
Missed scheduled dose protocol
If you forget to take a single dose, take it when you remember unless the next scheduled dose is within about four hours. If the next dose is close, skip the i did not take a dose and continue with your normal dosing schedule. Never double-up doses to make up for a missed one.
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Some combinations can increase risk or change quetiapine levels. Talk through all medicines and supplements together with your clinician. Notable the interactional flow among participants categories include:
- Strong CYP3A4 inhibitors (for example ketoconazole, itraconazole, ritonavir, clarithromycin) which can raise quetiapine concentrations
- Strong CYP3A4 inducers (for example rifampicin, carbamazepine, phenytoin, The medicinal herb St Johns wort) which can reduce quetiapine exposure
- Central nervous system depressants such as benzodiazepines, certain antihistamines, alcohol and cannabis that increase sedation and impairment
- Antihypertensive drugs that may add to quetiapine-related low blood pressure and dizziness
- Certain older antipsychotics and other medicines known to prolong the QT interval such as pimozide or drugs like halofantrine
This list is not comprehensive. Always show your prescriber a complete list of current medicines, including herbal products and over-the-counter items. For interpersonal engagements create opportunities for collaboration. affecting safe driving see Vigilant monitoring for daily living tips.
Event monitoring for daily living tips
- Clinical benefit can take several weeks. Keep follow-up appointments so your clinician can review response and adjust dosing.
- Baseline and ongoing checks may include weight, fasting blood glucose and lipid profile, particularly for longer courses.
- Watch for any new or worsening mood changes, agitation, restlessness or suicidal thinking and report these immediately.
- Quetiapine commonly causes drowsiness and slower reaction times. Do not drive or operate equipment until you understand how the medicine affects you.
- To reduce dizziness when standing, rise slowly from sitting or lying positions.
- Before using any new over-the-counter cold or sleep remedies, ask a pharmacist whether they are safe with quetiapine.
Medical adverse reactions and when to seek emergency help
Seek immediate medical attention if any of the following occur:
- Allergic signs: rash, hive-like swellings, swelling of the face, lips or throat, or difficulty breathing
- Very rapid or irregular heartbeat, fainting, or severe lightheadedness
- High fever with muscle stiffness, confusion or reduced consciousness (possible neuroleptic malignant syndrome)
- Severe infection signs such as persistent fever, sore throat, unexplained bruising or bleeding (possible blood cell problems)
- New or severe uncontrolled movements of the face, mouth, neck or limbs
- Seizure or loss of consciousness
- Thoughts of harming yourself or others
Common but generally less serious effects include drowsiness, dry mouth, constipation, increased appetite and weight gain, and sexual possible side effects. If possible side effects persist or are bothersome, contact your prescriber to discuss dose changes or another way forward therapy.
Proper storage capacity determines how much you can keep. and safe disposal
- Place all medications beyond the reach and out of sight of children.
- Store at room temperature, ideally between 15 and 30 degrees C, in a dry place away from direct heat and sunlight.
- Do not use after the expiry date on the packaging. Return unused or out-of-date medicines to a community pharmacy for safe destruction rather than disposing of them in household rubbish or flushing them.
Choice other routes, medicines of a comparable nature and how to price: a guide (AUD)
Other atypical antipsychotics with similar uses include risperidone, olanzapine, aripiprazole, paliperidone, ziprasidone, lurasidone and clozapine. Drug choice depends on diagnosis, previous response, side effect profile and monitoring needs. For augmentation of antidepressants clinicians may also consider lithium, mirtazapine or bupropion in selected cases.
Indicative patient cost considerations in Australia (AUD)
- Many quetiapine products are subsidised under the Pharmaceutical Benefits Scheme (PBS). For PBS-subsidised prescriptions general patients typically pay around AUD 30 to 32 per prescription while concession card holders pay about AUD 7 to 8. These amounts can change with PBS updates.
- Private prescriptions (non-PBS) vary widely. Generic immediate-release quetiapine packs can cost roughly AUD 10 to 60 depending on strength and pack size; extended-release or brand-name items are commonly more expensive.
- Other PBS-listed antipsychotics usually have similar co-payments when prescribed for approved signals pointing to. Off-PBS prescribing, specialty formulations and injectable depot medications usually increase out-of-pocket costs.
- Clozapine carries additional requirements including enrolment in a real time monitoring program and regular blood tests; while PBS-listed, extra real time monitoring leads to additional time and latent potential indirect costs.
Prices and PBS listings are subject to change. For exact and current costs consult your local pharmacy along with the PBS website or tools.
The the status of being legal of residents in Australia and prescription access
- Schedule category: Quetiapine is classified as a Schedule 4 prescription-only medicine in Australia and requires a prescription from an authorised prescriber.
- PBS eligibility: Specific quetiapine strengths and signs indicating may be subsidised by the PBS. Subsidy depends on clinical signs indicating and relevant prescribing criteria.
- Personal importation and travel: Under TGA personal importation provisions, travellers may carry up to a three month supply for personal use. Keep medicines in original packaging where possible and carry a copy of your prescription. Declare medicines if requested at the border.
- Driving and workplace safety: Quetiapine can impair alertness. It is unlawful to drive while impaired. Do not drive or operate heavy machinery until you are confident the medication does not affect you.
- Misuse and off-label use: Using quetiapine as a routine sleep aid, sharing prescriptions or taking someone elses medicine is unsafe and discouraged.
- Disposal: Return unwanted or expired medicines to a community pharmacy for secure destruction rather than disposing of them in household waste.
Essential facts
- Start low and titrate slowly under medical supervision.
- Monitor weight, blood glucose and lipids during prolonged treatment.
- Report new eye problems, severe constipation, involuntary movements or suicidal thoughts without delay.
For more detailed checks and lifestyle advice see Managing life through surveillance of system activity tips. In an emergency call Triple Zero (000) or the Poisons Information Centre on 13 11 26 for urgent advice.
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